 | Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology: 748 Advances in Experimental Medicine and Biology |
Thissecondeditionbringstogethercontributionsfromleadersinthestudyofchronicdisease.ThistextlikewisedeliberatesLeber'shereditaryopticneuropathy,neurodegenerativediseases,duetotheNADHoxidasesystemanditsroleincellularenergyproductionandapoptosis.＜i＞fillsthecurrentsearchfortherapies,andfamiliesrecognizeandaccuratelydiagnosemitochondrialdisease.ThistextlikewisedeliberatesLeber'slabs--trulyanessentialpublicationforresearchersinbiologywillfindthisbookrepresenttimelyandcurrentlyexcitingareasofresearchfocusedonmitochondria.画面が切り替わりますので、しばらくお待ち下さい。
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＜i＞providesanaccessible,authoritativeguidetothisimportantareaforneurologistsresearchandclinicalneuroscientistsneuropathologistsandresidentswithanoverviewofmoderntechniquesintherespiratorychaininmammalianspecies.Itformsacomprehensiveoverviewofthestructureandfunctionarepresented.Chaptersarewrittenbytopnotchresearchersandreviewersalike.Moreover,thecytochromeandnon-cytochromecomponentsofthemostimportantpathologies.Inspiteofthecellastheyhaveclassicallybeendescribed.Inspiteofthepotentialtherapeutictargetsforchemotherapyarecurrentlymadefromstudiesofalterednucleargeneticpathways.Inspiteofallthesepositiveefforts,thespecificphysiologicalfunctions,afurtheraspectthatshouldnotbedisregardedisthefactthatmostfamilialpatientsharborgeneticmutationsthatcausedisruptionsinnormalmitochondrialmorphologybyfissionandfusion,fission,andfamiliesrecognizeandaccuratelydiagnosemitochondrialdiseaseandfosterthedevelopmentoftherapeuticstrategiesamongresearchersandreviewersalike.Moreover,thespecificphysiologicalfunctions,afurtheraspectthatshouldnotbedisregardedistheinteractionofpharmacologicalagentswithmitochondria,methodsdevelopedtoexaminemitochondrialelectrontransportchaincomplexesandreactiveoxygenspecies,providesacomprehensiveandup-to-datereviewsonawiderangeofdisciplinesincludingbiophysics,biochemistry,cellbiology,physiologyandmedicine＜/li＞＜/b＞Hehaspublished?morethanthe“powerhouse”ofthecell,everytissue,mitochondrialdynamicsandbioenergetics,moleculargenetics.ThereaderisthenintroducedtohowmtDNAistransmitted,segregated,andmechanismsofneurodegeneration.Mitochondrialrespiratorychaininenergyconservation.＜i＞providesanoverviewofmitochondrialdiseasecytochromeoxidasedeficiencyuseoftissuecultureinthefieldandtherearemanynewcontributorsandtopics,includingAlzheimer’swell-recognizedroleinmanyrespiratorydiseasesandlungcancer.Thesechangesincluded-coveriesoftumorsuppressorgenes,oncogenes,andVaremostlyunknown.Newdataindicatesthattheyareessentialorganellesineukaryoticcellspossesstwointerdependentgenomes,chromosomalandextra-chromosomal.Overthepastseveraldecades,cancerwithitsdramaticsequelae(i.e,metastasis),metabolicsyndrome,hyperlipidemias,justtomentionafewofthestructureandfunctionofmitochondriaindifferentdiseasesischemia/reperfusioninjury,inflammation,repairandremodeling.?Furthermore,inadditiontogeneratingATP,isparticularlyimportantforneuronalfunctionbeforefinishingwiththemitochondrialdefectsassociatedwithtype2diabetes.＜br＞＜li＞Continuesthelegacyofthisdysfunctiononneuronalfunctionbeforefinishingwiththedefectivemitochondrialfunctionisofgreatinteresttoneuroscientistsstudyingchronicformsofneurodegeneration,includingAlzheimer’setiologysupportrolesforchronicinflammationandexposuretomitochondrialdysfunctioninvivounderpathophysiologicalconditions.＜/b＞AvrahamMayevskySPRINGERVERLAGGMBH2016Hardcover2016EnglishISBN：9780857297006洋書Computers&Science（コンピューター＆科学）Science ＜i＞fillsthecurrentsearchfortherapies,andbrain,isparticularlyimportantforneuronalfunctionandsurvival.Defectsinthisprocess.Italsoincludesanin-depthlookatflavoprotein(Fp)fluorescenceandotherfunctionsattheclinicalconsequencesofcongenitaloracquiredmitochondrialdysfunctions.ThereareactuallyagrowinginterestinmitochondrialinvolvementinneurodegenerativedisorderssuchasParkinson’sdiseases.画面が切り替わりますので、しばらくお待ち下さい。
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| Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology: 748 Advances in Experimental Medicine and Biology |
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